Monoclonal Gammopathy of Undetermined Significance with Metastatic Carcinoma – A Rare Presentation

نویسندگان

  • Meenakshi Vedavyasan Dept. of Biochemistry, Pondicherry Institute of Medical Sciences, Pondicherry, India
  • Mijil Anand Justin Dept. of Pathology, Pondicherry Institute of Medical Sciences, Pondicherry, India
  • Renu G’Boy Varghese Dept. of Pathology, Pondicherry Institute of Medical Sciences, Pondicherry, India
  • Thomas Alexander Dept. of Gastroenterology, Pondicherry Institute of Medical Sciences, Pondicherry, India
چکیده مقاله:

The presence of a low level of M protein in the peripheral blood <3gm/dl which is below the required cut off for the diagnosis of plasma cell myeloma is known as monoclonal gammopathy of undetermined significance (MGUS). Elevated levels of serum M protein and detection of M band on serum protein electrophoresis (SPE) can occur in chronic diseases not related to B cell disorders and not always diagnostic for B cell dyscrasias. It can also be seen in non hematological malignancies as seen in our case. We present a case of MGUS in a 59yr male patient, previously diagnosed and surgically treated for carcinoma prostate and colon. Serum electrophoresis revealed an M Band – monoclonal protein of 1.9 gm/dl. Urine for Bence Jones proteins was negative and his skeletal X-rays did not reveal lytic lesions.  Bone marrow aspiration revealed metastatic carcinoma. Plasma cells formed 1% of the bone marrow differential count.

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Monoclonal gammopathy of undetermined significance.

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عنوان ژورنال

دوره 7  شماره 1

صفحات  58- 62

تاریخ انتشار 2012-01-01

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